報(bào)告時(shí)間：2025年9月1日（星期一）15:00-17:00
報(bào)告地點(diǎn)：昇華樓616會(huì)議室
報(bào) 告 人：René Michael Koenigs 教授
工作單位：亞琛工業(yè)大學(xué)、拜羅伊特大學(xué)
舉辦單位：化學(xué)與化工學(xué)院，高值催化轉(zhuǎn)化與反應(yīng)工程安徽省重點(diǎn)實(shí)驗(yàn)室，安徽省柔性智能材料創(chuàng)制與應(yīng)用工程研究中心
報(bào)告簡介：
Photochemistry offers unique opportunities for reaction discovery by enabling the generation and control of highly reactive intermediates under mild conditions. Our research explores how visible-light activation can unlock novel reactivity modes of species such as carbenes, radicals and nitrenes, providing access to previously unattainable bond constructions and heterocyclic frameworks. This approach highlights photochemistry as a powerful platform for advancing modern synthetic methodology.
Herein, we present our recent advances in photochemical and photocatalytic carbene and nitrene transfer reactions. Emphasis will be placed on strategies to access either singlet or triplet states and how this electronic control enables distinct applications in synthetic methodology. Approaches to modulate nitrene reactivity via single-electron transfer pathways or direct photoexcitation will be highlighted, supported by mechanistic and computational studies that have guided the discovery of advanced cycloaddition chemistry.
We further outline an international, collaborative research program that integrates fundamental reactivity studies, reaction development, and mechanistic insight with translational applications in drug discovery. This work demonstrates how photochemical methods can unlock the potential of reactive intermediates and convert fundamental discoveries into new strategies for the synthesis of therapeutic candidates. Together, these studies highlight photochemistry as a powerful driver of innovation at the interface of fundamental and applied research.
報(bào)告人簡介：
René Michael Koenigs（雷內(nèi)-麥克-柯尼希斯）教授，博士畢業(yè)于德國亞琛工業(yè)大學(xué)。2015年加入亞琛工業(yè)大學(xué)有機(jī)化學(xué)研究所，任助理教授，2022年-至今為教授。2025年4月加入拜羅伊特大學(xué)，任教授，有機(jī)化學(xué)方向主任。主要研究方向?yàn)榭ㄙe和氮賓轉(zhuǎn)移反應(yīng)及其應(yīng)用。Koenigs教授入選安徽省外國專家人才項(xiàng)目（Anhui Province Foreign Expert Talent Program, 2025），榮獲澳大利亞研究委員會(huì)未來研究員計(jì)劃（Australian Research Council Future Fellowship, 2023）；亞琛工業(yè)大學(xué)FAMOS卓越領(lǐng)導(dǎo)力獎(jiǎng)（RWTH Aachen FAMOS award for excellence in leadership, 2021）。相關(guān)研究成果在Science、Nature Commun、Angew. Chem. Int. Ed.等期刊發(fā)表。
